Four riders died in the event last year and another was killed in 2015.
The race is one of the highlights of the motorbike racing calender.
Each year thousands of fans travel to the island in the middle of the Irish Sea to watch riders compete in the 37-and-a-quarter mile lap exceeding speeds of 200mph.
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The riders are going so fast, some fans have trouble snapping a photo of them.
WARNING: The video below contains graphic images.
