Indications
Cytoxan is typically used:
After surgery for early-stage breast cancer to reduce the risk of recurrenceBefore surgery to shrink advanced-stage tumorsAfter surgery to treat advanced-stage tumors
This drug is also used to treat ovarian cancer, lymphoma, leukemia, multiple myeloma, mycosis fungoides, neuroblastoma, and retinoblastoma.
How It Works
Cytoxan treats cancer by damaging the cancer cell DNA in a way that prevents the cells from dividing and kills them. This drug will also affect healthy cells but will have less effect on most healthy cells because they divide more slowly.
Some of the healthy cells that may be affected by this drug include blood, digestive tissue, and hair follicle cells.
Drug Combinations
Cytoxan is often combined with Adriamycin in a chemotherapy infusion to treat breast cancer. This combination is called AC. In rare instances, these drugs may also be combined with fluorouracil and called FAC or CAF.
Another chemotherapy combination used for breast cancer is Taxotere and Cytoxan. There also is a very old but still commonly used mixture called CMF, which has Cytoxan, methotrexate, and 5-fluorouracil.
Efficacy
The therapeutic effects of Cytoxan are not the same for all types of cancer, and research studies are used to determine which subtypes may benefit from various chemotherapy combinations.
A study published in 2017 looked at the combination of Cytoxan and the drug docetaxel as neoadjuvant chemotherapy in HER2-negative primary breast cancer. Researchers found this combination was effective against triple-negative breast cancer, but not other forms.
In another 2017 study, Cytoxan was used in a combination called ACTHP that had an 85% success rate in clearing cancer from axillary nodes in HER2-positive early-stage cancer.
The other drugs in the combination were:
DoxorubicinTrastuzumabPertuzumab
Research published in Clinical Cancer Research suggested that the molecular subtype luminal A breast cancer didn’t benefit at all from adjuvant chemotherapy with Cytoxan.
Dosage and Administration
Cytoxan can be given either intravenously as a solution or by mouth in pill form.
For IV Cytoxan, dosages and infusion frequency varies depending on multiple factors, including cancer type and body weight.
For Cytoxan tablets, the dosage is also variable and based on cancer type, weight, other treatments you may be on, and how you’ve responded to other treatments.
Risks and Side Effects
The risks and side effects of Cytoxan chemotherapy include:
Allergic reactions (shortness of breath, swelling of feet or ankles, rash, swollen throat) Potential harm to a fetus Possible infertility Neutropenia (low blood count that leads to a greater risk of infection) Hair loss Nausea Vomiting Diarrhea Fatigue Irritation in the mouth Menstrual cycle interruptions Brittle nails
If you have any of these symptoms, call your healthcare provider right away:
Fever of 100. 5 degrees F or higherPainful or bloody urineBlack and sticky stools or bloody stoolsUnusual bruises or bleedingPersistent cough or pneumonia
To help prevent kidney and bladder infections, be sure to drink plenty of fluids so that you will urinate often. It’s also recommended that you avoid alcohol and caffeine, as they can be very dehydrating for your body and exacerbate some of the effects of Cytoxan.
For pain relief, ibuprofen is considered safer alongside Cytoxan than aspirin.
Cytoxan significantly impacts the immune system, so getting vaccinations is usually not recommended while you’re undergoing treatment.
